Please specify metabolites (exposure) and outcome of interestCausal analysis is based on Mendelian randomization (MR) which leverages genetic variants such as single-nucleotide polymorphisms (SNPs) as instrumental variables (IV) to estimate exposure-outcome associations. The growing number of mGWAS studies and two-sample MR method permit causal analysis between metabolite and outcome of interest as described below:
1. Select a metabolite of interest (exposure):Due to its complex and computing intensive nature, MR analysis is typically performed with one metabolite/exposure at a time, to make sure that each step is performed properly as well as to avoid performance issue (max 5). |
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