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Dose-response analysis was developed by the field of toxicology to identify the concentration at which a biological assay responds to chemical exposure. Dose response analysis require doses or exposure levels span a wide range to perform curve fitting. Two dose types are currently accepted:

  1. Repeated Dosing: this experimental design includes a control group (dose = 0) and at least three different dose groups, typically with the same number of replicates in each group.
  2. Continuous Exposure: this data is usually from observational exposomics studies with doses/exposures measured from individuals with different exposure levels;

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Discrete
An example data to study dose-response effect using metabolomics. BT549 breast cancer cells were treated with etomoxir discrete concentrations that spanned 10-200 μM Doses: 0, 10, 50, and 200 uM with three replicates at each dose (details).
E-waste Metadata
An exposomics example data to study dose-response effect of exposome with heavy metals in e-waste workers. The dataset was generated with UPLC-Q/Exactive (C18 ESI-). The heavy metal (Lanthanum) is considered as a continuous exposure dose.(details).